What infectious disease contributed to the downfall of the Aztec Empire?
Answer Smallpox
Smallpox was brought by the Spanish to the Aztec territory and played a crucial part in the collapse of the Aztec Empire. Smallpox moved slowly to Tepeaca and Tlaxcala from May to September 1520, and by the autumn, Cortes returned to find many leaders and lords dead from the disease, leaving the Empire vulnerable.
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