These two lab mice are complete opposites; one is constantly scheming to take over the world and one is clueless and goofy.

Answer Pinky and the Brain

Pinky is the bumbling and completely clueless best friend to the evil and always-scheming Brain. The two mice are residents of Acme Labs, and while Brain comes up with wildly impossible ways to take over the world, Pinky always seems to help put those schemes on ice one way or another. The two, however, are best friends.

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