The Destroyer was an ancient Asgardian robot that was mostly used to protect Odin's Vault, but it was often capable of being used as a weapon. What character used it against Thor in the MCU?

Answer Loki

The Destroyer assassinated three Frost Giants within Odin's Vault after Odin gave a signal interrupting a ritual to crown Thor as Asgard's ruler. When Loki usurped Asgard's throne, he commandeered the Destroyer and sent it to assassinate his brother Thor.

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