In the cleverly-titled episode "Alone Again, Natura-Diddily," Ned Flanders loses his wife in a tragic accident. How does she die?

Answer Killed by a t-shirt cannon

In the episode, Maude is at the racetrack with Ned and The Simpsons, and on a trip to get hot dogs, she gets pummeled by t-shirts from a cannon, and they knock her over the guardrail, and she falls to the ground several stories below. Dr. Hibbert pronounces her dead.

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