In one episode, Homer goes blind after staying up all night to eat 64 what, leading to an uptick of food-eating contests by viewers?

Answer Slices of American cheese

This scene from the episode called "Rosebud" has little to do with the overall plot, but The Simpsons animator David Silverman and creator Matt Groening have describes the sequence where Homer eats 64 slices of American cheese as "one of the most hilarious segments ever done".

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