Creating the "Kingdom of Spain," what queen united her kingdom with that of King Ferdinand II's?

Queen of Castile, Isabella I was alive for only thirty years, but during that time she combined her kingdom with that of King Ferdinand II of Aragon and financed the expedition of Italian explorer, Christopher Columbus. Together with her husband, the power couple was deemed the "Catholic Monarchs," as they expelled all Muslims and Jews from Spain during the Inquisition.

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